Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287642 | 0.82 | KMT2A (0.53) | GSK3BMAPTALDH1A1KMT2AERCC5 | |
| SCHEMBL867151 | 0.77 | GSK3B (0.55) | GSK3BMAPTERCC5FEN1KDM4E | |
| SCHEMBL21747244 | 0.76 | KMT2A (0.50) | GSK3BMAPTALDH1A1KMT2ACES2 | |
| SCHEMBL10513754 | 0.75 | GSK3B (0.44) | GSK3BMAPTALDH1A1KMT2AERCC5 | |
| SCHEMBL29171625 | 0.73 | NPC1 (0.56) | GSK3BMAPTNPC1RAB9AHRH3 | |
| SCHEMBL826542 | 0.72 | SLC7A5 (0.51) | MAPTALDH1A1KMT2AKDM4EALOX15 | |
| SCHEMBL15905943 | 0.72 | SLC7A5 (0.51) | MAPTALDH1A1KMT2AKDM4EALOX15 | |
| SCHEMBL14679505 | 0.72 | ANPEP (0.38) | — | |
| SCHEMBL16552727 | 0.71 | GSK3B (0.70) | GSK3BMAPTALDH1A1KMT2AERCC5 | |
| SCHEMBL600674 | 0.71 | ERCC5 (0.72) | GSK3BMAPTALDH1A1KMT2AERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4028381-A | ANTIANXIETY AND ANTIDEPRESSANT AGENTS | CIBA-GEIGY CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-4022801-A | ANTIANXIETY AND ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1977-05-10 | — | — | US | disclosed |
| US-3947585-A | ANTIANXIETY, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |