Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747244 | 0.93 | KMT2A (0.50) | KMT2AMAPTALDH1A1GSK3BHRH3 | |
| SCHEMBL7284408 | 0.83 | NPC1 (0.54) | KMT2AMAPTALDH1A1GSK3BMEN1 | |
| SCHEMBL7210582 | 0.83 | NPC1 (0.56) | KMT2AHRH3MEN1NPC1RAB9A | |
| SCHEMBL3392114 | 0.83 | KMT2A (0.51) | KMT2AMAPTALDH1A1GSK3BMEN1 | |
| SCHEMBL7287661 | 0.82 | MAPT (0.52) | KMT2AMAPTALDH1A1MEN1NPC1 | |
| SCHEMBL11680952 | 0.82 | GSK3B (0.52) | KMT2AMAPTALDH1A1GSK3BHRH3 | |
| SCHEMBL7285554 | 0.82 | KMO (0.45) | KMT2AALDH1A1MEN1HSD11B1L3MBTL1 | |
| SCHEMBL7285961 | 0.81 | ERCC5 (0.49) | KMT2AALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL27427396 | 0.79 | GSK3B (0.51) | MAPTALDH1A1GSK3BNPC1RAB9A | |
| SCHEMBL7275966 | 0.79 | MMP1 (0.53) | KMT2AMAPTALDH1A1GSK3BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801058-B1 | Arylthio, -sulfinyl and -sulfonyl pyrrole insecticidal agents | AMERICAN CYANAMID CO (US) | 2001-10-10 | — | — | EP | disclosed |
| US-5817691-A | Arylthio, -sulfinyl and -sulfonyl pyrrole insecticidal agents | AMERICAN CYANAMID COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0801058-A1 | Arylthio, -sulfinyl and -sulfonyl pyrrole insecticidal agents | American Cyanamid Company (US) | 1997-10-15 | — | — | EP | disclosed |
| CN-1030986-C | Pyrrolopyrazine | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | CN | disclosed |
| US-5292732-A | Pyrrolopyrazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| CN-1068328-A | PYRROLOPYRAZINE | HOFFMANN LA ROCHE (CH) | 1993-01-27 | — | — | CN | disclosed |
| EP-0521368-A1 | Bi- and tetracyclic pyrrolopyrazines | F. HOFFMANN-LA ROCHE AG (CH) | 1993-01-07 | — | — | EP | disclosed |