Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.60 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673946 | 0.82 | SIRT1 (0.78) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL18715401 | 0.81 | SIRT1 (0.59) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL1674922 | 0.77 | SIRT1 (0.79) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL8543514 | 0.75 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL8545315 | 0.75 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL8545321 | 0.75 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL8543519 | 0.75 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL3575730 | 0.75 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2SIRT2SIRT3ALOX15 | |
| SCHEMBL3484154 | 0.75 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15SMN1; SMN2 | |
| SCHEMBL6245012 | 0.74 | MAPKAPK2 (1.00) | SIRT1MAPKAPK2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4009181-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-22 | — | — | US | disclosed |