Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6006301 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL10572642 | 0.90 | CYP1A2 (0.51) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL10720726 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL8795722 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL21629502 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL8795716 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL20509384 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL10535907 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL5131881 | 0.86 | CYP1A2 (0.56) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL6632291 | 0.86 | CYP1A2 (0.54) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103228643-B | As the benzoxazole derivative of histamine h 4 receptor part | BIOPROJET (FR) | 2015-11-25 | — | — | CN | disclosed |
| CN-103228643-A | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET SOC CIV | 2013-07-31 | — | — | CN | disclosed |
| CN-1143364-A | 5-HT3 receptor agonist, novel thiazole derivative, and intermediate thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1997-02-19 | — | — | CN | disclosed |
| US-4028323-A | WITH A SUBSTITUTED AMINOBENZENE | CIBA-GEIGY AG (CH) | 1977-06-07 | — | — | US | disclosed |