Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13937944 | 0.83 | TDP1 (0.46) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL13937923 | 0.83 | TDP1 (0.46) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL4715603 | 0.80 | TDP1 (0.50) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL31688086 | 0.80 | TDP1 (0.50) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL16169017 | 0.75 | TDP1 (0.53) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL18073625 | 0.75 | TDP1 (0.53) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL29381145 | 0.74 | TDP1 (0.57) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL166122 | 0.74 | TDP1 (0.57) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL6656473 | 0.74 | TDP1 (0.57) | TDP1ALDH1A1LMNATSHRTP53 | |
| SCHEMBL28798215 | 0.73 | TDP1 (0.47) | TDP1ALDH1A1LMNATSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4044123-A | ANTIBIOTICS | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |
| US-4002608-A | ANTIBACTERIALS | SCHERING CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |
| US-4002742-A | 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor | SCHERING CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |