Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22591141 | 0.84 | LPAR1 (0.56) | TMEM97SIGMAR1LPAR1LPAR5F2 | |
| SCHEMBL4081027 | 0.83 | LPAR1 (0.53) | TMEM97SIGMAR1TP53MAPTCYP3A4 | |
| SCHEMBL3455287 | 0.77 | HSP90AA1 (0.66) | TMEM97SIGMAR1TP53MAPTCYP3A4 | |
| SCHEMBL1169177 | 0.74 | MEN1 (0.50) | TMEM97SIGMAR1C5AR1LPAR1LPAR5 | |
| SCHEMBL4072443 | 0.74 | TMEM97 (0.50) | TMEM97SIGMAR1TP53MAPTCYP3A4 | |
| SCHEMBL1169641 | 0.74 | SMN1; SMN2 (0.55) | TP53MAPTCYP3A4LPAR1LPAR5 | |
| SCHEMBL5365302 | 0.73 | TSHR (0.52) | TMEM97SIGMAR1TP53MAPTPOLB | |
| SCHEMBL3455752 | 0.72 | LPAR1 (0.57) | LPAR1LPAR5F2F10F7 | |
| SCHEMBL6317869 | 0.71 | PPARA (0.48) | TMEM97SIGMAR1CYP3A4NPC1RAB9A | |
| SCHEMBL6325127 | 0.71 | TMEM97 (0.49) | TMEM97SIGMAR1CYP3A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778985-B2 | Inhibiting amyloid-beta peptide/rage interaction at the blood-brain barrier | THE UNIVERSITY OF ROCHESTER (US) | 2014-07-15 | — | — | US | claimed |
| EP-3307781-B1 | ANTIBODIES, COMPOUNDS AND SCREENS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA | BROAD INST INC (US) | 2020-10-28 | — | — | EP | disclosed |
| US-8778985-B2 | Inhibiting amyloid-beta peptide/rage interaction at the blood-brain barrier | THE UNIVERSITY OF ROCHESTER (US) | 2014-07-15 | — | — | US | disclosed |
| US-20110039908-A1 | Inhibiting Amyloid-Beta Peptide/Rage Interaction At The Blood-Brain Barrier | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-17 | — | — | US | disclosed |
| EP-1993527-A4 | INHIBITING AMYLOID-BETA PEPTIDE/RAGE INTERACTION AT THE BLOOD-BRAIN BARRIER | UNIV ROCHESTER (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1993527-A2 | INHIBITING AMYLOID-BETA PEPTIDE/RAGE INTERACTION AT THE BLOOD-BRAIN BARRIER | THE UNIVERSITY OF ROCHESTER (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007089616-A2 | INHIBITING AMYLOID-BETA PEPTIDE/RAGE INTERACTION AT THE BLOOD-BRAIN BARRIER | THE UNIVERSITY OF ROCHESTER (US) | 2007-08-09 | — | — | WO | disclosed |