Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 8/20 | 0.53 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169293 | 0.83 | TMEM97 (0.51) | LPAR1C5AR1TMEM97SIGMAR1TP53 | |
| SCHEMBL709398 | 0.81 | LPAR1 (0.72) | LPAR1LPAR2 | |
| SCHEMBL706501 | 0.80 | LPAR1 (0.72) | LPAR1LPAR2LPAR5 | |
| SCHEMBL8337381 | 0.78 | CYP3A4 (0.48) | LPAR1TMEM97SIGMAR1LPAR2MGLL | |
| SCHEMBL708961 | 0.78 | LPAR1 (0.64) | LPAR1C5AR1LPAR2 | |
| SCHEMBL714547 | 0.78 | LPAR1 (0.69) | LPAR1LPAR2 | |
| SCHEMBL708439 | 0.78 | LPAR1 (0.67) | LPAR1LPAR2LPAR5 | |
| SCHEMBL709233 | 0.78 | LPAR1 (0.64) | LPAR1C5AR1LPAR2 | |
| SCHEMBL3455287 | 0.77 | HSP90AA1 (0.66) | TMEM97SIGMAR1TP53MAPTCYP3A4 | |
| SCHEMBL709148 | 0.77 | LPAR1 (0.78) | LPAR1LPAR2LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778985-B2 | Inhibiting amyloid-beta peptide/rage interaction at the blood-brain barrier | THE UNIVERSITY OF ROCHESTER (US) | 2014-07-15 | — | — | US | claimed |
| EP-3307781-B1 | ANTIBODIES, COMPOUNDS AND SCREENS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA | BROAD INST INC (US) | 2020-10-28 | — | — | EP | disclosed |
| US-8778985-B2 | Inhibiting amyloid-beta peptide/rage interaction at the blood-brain barrier | THE UNIVERSITY OF ROCHESTER (US) | 2014-07-15 | — | — | US | disclosed |
| EP-1993527-A4 | INHIBITING AMYLOID-BETA PEPTIDE/RAGE INTERACTION AT THE BLOOD-BRAIN BARRIER | UNIV ROCHESTER (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1993527-A2 | INHIBITING AMYLOID-BETA PEPTIDE/RAGE INTERACTION AT THE BLOOD-BRAIN BARRIER | THE UNIVERSITY OF ROCHESTER (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007089616-A2 | INHIBITING AMYLOID-BETA PEPTIDE/RAGE INTERACTION AT THE BLOOD-BRAIN BARRIER | THE UNIVERSITY OF ROCHESTER (US) | 2007-08-09 | — | — | WO | disclosed |