Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 8/20 | 0.62 |
| ▸ | CDC25A | P30304 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | VDR | P11473 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLA1 | P09884 | 2/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11694295 | 1.00 | NPC1L1 (0.62) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11846892 | 1.00 | NPC1L1 (0.62) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11845925 | 0.91 | NPC1L1 (0.75) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11845915 | 0.91 | NPC1L1 (0.75) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11691093 | 0.88 | POLB (0.49) | NPC1L1CDC25AUSP2VDRPOLA1 | |
| SCHEMBL27849151 | 0.86 | NPC1L1 (0.67) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11786454 | 0.84 | NPC1L1 (0.58) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11786452 | 0.84 | NPC1L1 (0.58) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11691110 | 0.81 | NPC1L1 (0.53) | NPC1L1CDC25AUSP2LMNAMEN1 | |
| SCHEMBL11691103 | 0.81 | NPC1L1 (0.53) | NPC1L1CDC25AUSP2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001220-A | 6-(Aminated methyl)-3β-oxy-5α-(cholestane-stigmastane)-5,6-diols, salts thereof, and intermediates thereto | G. D. SEARLE & CO. (US) | 1977-01-04 | — | — | US | disclosed |
| US-3960904-A | 6-Aminomethylated 3-oxygenated cholest-5-enes | G. D. SEARLE & CO. (US) | 1976-06-01 | — | — | US | disclosed |