Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1169279 | 0.99 | CHRNA7 (0.54) | CHRNA7HRH3ALDH1A1LMNAMEN1 | |
| SCHEMBL1169846 | 0.81 | L3MBTL3 (0.53) | HRH3GPR119 | |
| SCHEMBL1169529 | 0.80 | CHRNA7 (0.55) | CHRNA7HRH3ALDH1A1LMNAMEN1 | |
| SCHEMBL3856898 | 0.80 | HRH3 (0.57) | HRH3ALDH1A1LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1169593 | 0.80 | L3MBTL3 (0.52) | HRH3GPR119 | |
| Hydrochloric Acid SCHEMBL3858283 | 0.79 | HRH3 (0.56) | HRH3ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4667174 | 0.78 | HRH3 (0.53) | HRH3LMNAGPR119 | |
| SCHEMBL3859432 | 0.74 | HRH3 (0.51) | HRH3ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1169532 | 0.74 | CHRNA7 (0.56) | CHRNA7HRH3ALDH1A1LMNAMEN1 | |
| SCHEMBL15624886 | 0.74 | CHRNA7 (0.94) | CHRNA7HRH3ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492375-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2013-07-23 | — | — | US | claimed |
| US-20110039833-A1 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-02-17 | — | — | US | claimed |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | claimed |
| US-8492375-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2013-07-23 | — | — | US | disclosed |
| US-8492375-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2013-07-23 | — | — | US | disclosed |
| US-20110039833-A1 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-02-17 | — | — | US | disclosed |
| US-20110039833-A1 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-02-17 | — | — | US | disclosed |
| US-7846922-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2010-12-07 | — | — | US | disclosed |
| US-7846922-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2010-12-07 | — | — | US | disclosed |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039833-A1 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS | HRH3, HRH4, HRH1 | CHRNA7 34/4885HRH3 1/4885ALDH1A1 1855/4885 |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | HRH3, HRH4, HRH1 | CHRNA7 14/4885HRH3 1/4885ALDH1A1 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.