SCHEMBL11707166

SCHEMBL11707166

O=C(O)CCCc1ccc2c(c1)CCc1ccccc1C2=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 5/20 0.52
CYP1A2 P05177 2/20 0.51
MAPK14 Q16539 3/20 0.50
HDAC3 O15379 1/20 0.49
MAPK1 P28482 1/20 0.49
ADRA1A P35348 1/20 0.49
HDAC4 P56524 1/20 0.49
SLC6A3 Q01959 1/20 0.49
HDAC1 Q13547 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49
HDAC5 Q9UQL6 1/20 0.49
CYP2D6 P10635 1/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11701595 0.96 AKR1B1 (0.51) AKR1B1CYP1A2MAPK14HDAC3MAPK1
SCHEMBL11706524 0.95 MAPT (0.51) AKR1B1CYP1A2MAPK14HDAC3MAPK1
SCHEMBL503763 0.93 CYP1A2 (0.55) AKR1B1CYP1A2HDAC3MAPK1ADRA1A
SCHEMBL24440105 0.83 CYP1A2 (0.56) CYP1A2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL11088738 0.83 AKR1B1 (0.74) AKR1B1MAPK14SRD5A1SRD5A2CES1
SCHEMBL11705908 0.81 MAPK14 (0.46) AKR1B1MAPK14MAPK1SMN1; SMN2SRD5A1
SCHEMBL11197534 0.81 AKR1B1 (0.60) AKR1B1
SCHEMBL11706674 0.80 MAPK14 (0.45) AKR1B1MAPK14SRD5A1SRD5A2
SCHEMBL11700580 0.79 MAPK14 (0.44) AKR1B1MAPK14
SCHEMBL9133025 0.79 PDK2 (0.53) AKR1B1FFAR4SRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4038299-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC SYNTEX (U.S.A.) INC. (US) 1977-07-26 US disclosed
US-3966820-A ANALGESICS, ANTIINFLAMMATORY, ANTIPYRETICS SYNTEX (U.S.A.) INC. (US) 1976-06-29 US disclosed