⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170167 | 0.93 | EPHX1 (0.64) | — | |
| SCHEMBL28428629 | 0.91 | EPHX1 (0.68) | — | |
| SCHEMBL6500219 | 0.86 | — | — | |
| SCHEMBL16824229 | 0.81 | EPHX1 (0.59) | — | |
| SCHEMBL590532 | 0.81 | EPHX1 (0.59) | — | |
| SCHEMBL9395279 | 0.80 | EPHX1 (0.53) | — | |
| SCHEMBL968307 | 0.79 | — | — | |
| SCHEMBL383296 | 0.79 | — | — | |
| SCHEMBL988903 | 0.78 | ACHE (0.60) | — | |
| SCHEMBL361310 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976340-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-01-27 | — | — | EP | claimed |
| WO-2014146490-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | claimed |
| EP-1863756-A1 | BIARYL DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-12 | — | — | EP | claimed |
| WO-2006102645-A1 | BIARYL DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-28 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | claimed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | claimed |
| US-5693634-A | FOR SYSTEMIC AND TOPICAL TREATMENT OF HUMANS AND ANIMALS; VETERINARY MEDICINE | GLAXO WELLCOME S.P.A. (IT) | 1997-12-02 | — | — | US | claimed |
| EP-0773945-A1 | ACYL IMIDAZOPYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1997-05-21 | — | — | EP | claimed |
| EP-0728135-A1 | UREA DERIVATIVES | GLAXO WELLCOME S.p.A. (IT) | 1996-08-28 | — | — | EP | claimed |
| EP-0722449-A1 | BOROPEPTIDE INHIBITORS OF THROMBIN WHICH CONTAIN A SUBSTITUTED PYRROLIDINE RING | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-24 | — | — | EP | claimed |
| WO-1996003404-A1 | ACYL IMIDAZOPYRIDINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-02-08 | — | — | WO | claimed |
| WO-1995013278-A1 | UREA DERIVATIVES | GLAXO WELLCOME S.P.A. (IT) | 1995-05-18 | — | — | WO | claimed |
| WO-1995009859-A1 | BOROPEPTIDE INHIBITORS OF THROMBIN WHICH CONTAIN A SUBSTITUTED PYRROLIDINE RING | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-13 | — | — | WO | claimed |
| EP-0390693-A1 | Thioformamide derivatives | RHONE-POULENC SANTE (FR) | 1990-10-03 | — | — | EP | claimed |
| EP-0303934-A1 | 2-Cyano-2-oximino-acetamides | BAYER AG (DE) | 1989-02-22 | — | — | EP | claimed |
| EP-3400223-A1 | MICROBIOCIDAL OXADIAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2018-11-14 | — | — | EP | disclosed |
| US-4195090-A | ADRENERGIC BLOCKING AGENTS | CIBA-GEIGY CORPORATION (US) | 1980-03-25 | — | — | US | disclosed |
| US-4115575-A | CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |