Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | BLM | P54132 | 2/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 4/20 | 0.66 |
| ▸ | THPO | P40225 | 2/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | MTOR | P42345 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11721722 | 0.93 | KDM4E (0.71) | KDM4EBLMPMP22MAPTSMN1; SMN2 | |
| Bromide SCHEMBL11539891 | 0.88 | KDM4E (0.72) | KDM4EBLMPMP22MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11463952 | 0.84 | DRD1 (0.71) | KDM4EBLMPMP22MAPTSMN1; SMN2 | |
| SCHEMBL11543046 | 0.83 | CYP3A4 (0.69) | CYP2D6 | |
| SCHEMBL14288500 | 0.83 | SIGMAR1 (0.56) | MAPTLMNA | |
| Bromide SCHEMBL11528515 | 0.81 | DRD1 (0.71) | KDM4EBLMPMP22MAPTLMNA | |
| Bromide SCHEMBL11540315 | 0.81 | DRD1 (0.71) | KDM4EBLMPMP22MAPTLMNA | |
| Bromide SCHEMBL11707024 | 0.81 | KDM4E (1.00) | KDM4EBLMPMP22MAPTSMN1; SMN2 | |
| Bromide SCHEMBL11254711 | 0.81 | DRD1 (0.53) | KDM4EBLMPMP22MAPTLMNA | |
| SCHEMBL11157379 | 0.81 | DRD1 (0.70) | KDM4EBLMPMP22MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4052506-A | BENZAZEPINES | SMITHKLINE CORPORATION (US) | 1977-10-04 | — | — | US | disclosed |