Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.68 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823412 | 0.92 | POLB (0.63) | CXCR4TLR8POLBMEN1USP2 | |
| SCHEMBL10025495 | 0.89 | CXCR4 (0.71) | CXCR4TLR8POLBMEN1KMT2A | |
| SCHEMBL11718288 | 0.87 | CXCR4 (0.69) | CXCR4TLR8POLBUSP2KMT2A | |
| SCHEMBL11716008 | 0.85 | CXCR4 (0.62) | CXCR4TLR8POLBMEN1KMT2A | |
| SCHEMBL7164854 | 0.85 | CXCR4 (0.93) | CXCR4TLR8POLBKMT2ACYP1A2 | |
| SCHEMBL11712420 | 0.85 | CXCR4 (0.66) | CXCR4TLR8POLBMEN1KMT2A | |
| SCHEMBL11205606 | 0.82 | P2RX7 (0.71) | CXCR4TLR8MEN1KMT2ACYP1A2 | |
| SCHEMBL2443854 | 0.82 | CXCR4 (0.54) | CXCR4TLR8POLBMEN1USP2 | |
| SCHEMBL6196399 | 0.82 | CXCR4 (1.00) | CXCR4TLR8POLBKMT2ACYP1A2 | |
| SCHEMBL11713594 | 0.82 | BACE1 (0.64) | CXCR4TLR8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4059584-A | ANTIINFLAMMATORY | PFIZER (US) | 1977-11-22 | — | — | US | disclosed |
| US-4002623-A | Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines | PFIZER INC. (US) | 1977-01-11 | — | — | US | disclosed |