Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11714448 | 0.88 | POLB (0.42) | POLBKCNA5KMT2ATSHRDUSP3 | |
| SCHEMBL11820590 | 0.82 | KCNA5 (0.44) | KCNA5KMT2ATSHRMAPTNPSR1 | |
| SCHEMBL11713903 | 0.80 | POLB (0.35) | POLBMAPTALDH1A1KDM4EHTT | |
| SCHEMBL11711308 | 0.80 | MEN1 (0.40) | KCNA5KMT2ATSHRCYP2C19MEN1 | |
| SCHEMBL11818857 | 0.79 | KCNA5 (0.45) | KCNA5KMT2ATSHRCYP2C19MEN1 | |
| SCHEMBL11822611 | 0.77 | KCNA5 (0.43) | KCNA5KMT2ATSHRCYP2C19MEN1 | |
| SCHEMBL11819731 | 0.76 | EPHX1 (0.44) | KCNA5TSHRMAPTNPSR1CYP2C19 | |
| SCHEMBL11820818 | 0.76 | CYP2C19 (0.37) | KCNA5KMT2ATSHRMAPTNPSR1 | |
| SCHEMBL11712140 | 0.76 | SLC6A3 (0.39) | KCNA5KMT2ATSHRMAPTMEN1 | |
| SCHEMBL11819231 | 0.75 | CYP2C19 (0.39) | KCNA5TSHRMAPTNPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001241-A | GASTRIC ACID, ANTISECRETORY AGENTS | SMITHKLINE CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
| US-3966945-A | 2-Alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides for inhibiting gastric acid secretion | SMITHKLINE CORPORATION (US) | 1976-06-29 | — | — | US | disclosed |