Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10632634 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL11226593 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL10984015 | 0.77 | GAA (0.45) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL27792007 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL16999005 | 0.77 | TSHR (0.62) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL27925029 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL11713544 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL2093049 | 0.75 | TSHR (0.46) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL13512389 | 0.75 | TSHR (0.46) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL12721547 | 0.75 | TSHR (0.46) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001241-A | GASTRIC ACID, ANTISECRETORY AGENTS | SMITHKLINE CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
| US-3966945-A | 2-Alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides for inhibiting gastric acid secretion | SMITHKLINE CORPORATION (US) | 1976-06-29 | — | — | US | disclosed |