Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051158 | 1.00 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11713819 | 1.00 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11051156 | 1.00 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11051159 | 1.00 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL23315374 | 0.94 | MAPT (0.41) | MAPTPKMPOLBSLC6A1GABRA5 | |
| Trifluoroacetic Acid SCHEMBL11712875 | 0.90 | SLC6A2 (0.36) | MAPTPKMPOLBSLC6A1GABRA5 | |
| Trifluoroacetic Acid SCHEMBL11712865 | 0.90 | SLC6A2 (0.36) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11713259 | 0.85 | SLC6A1 (0.37) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL11079186 | 0.85 | SLC6A1 (0.37) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL11713269 | 0.85 | SLC6A1 (0.37) | MAPTPKMSLC6A1GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4012396-A | Processes and intermediates for cis or trans 2-or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters | HOFFMANN-LA ROCHE INC. (US) | 1977-03-15 | — | — | US | disclosed |
| US-3959294-A | Processes and intermediates for cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters | HOFFMANN-LA ROCHE INC. (US) | 1976-05-25 | — | — | US | disclosed |
| US-3957800-A | PROCESSES AND INTERMEDIATES FOR CIS OR TRANS 2- OR 3-(1-ACYL-3-VINYL-4-PIPERIDINE)ACETIC OR PROPIONIC ACID ESTERS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-18 | — | — | US | disclosed |