Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.49 |
| ▸ | PRKDC | P78527 | 12/20 | 0.49 |
| ▸ | ABL1 | P00519 | 9/20 | 0.48 |
| ▸ | EGFR | P00533 | 9/20 | 0.48 |
| ▸ | HCK | P08631 | 9/20 | 0.48 |
| ▸ | SRC | P12931 | 9/20 | 0.48 |
| ▸ | MTOR | P42345 | 9/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.47 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.45 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11717995 | 0.86 | PIK3CD (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11716973 | 0.84 | PDE2A (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11716880 | 0.84 | PDE2A (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11713714 | 0.82 | SLC2A1 (0.37) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11720860 | 0.81 | PKM (0.33) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11770601 | 0.81 | PDE2A (0.45) | — | |
| SCHEMBL11721578 | 0.81 | PDE2A (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11721437 | 0.80 | PDE2A (0.47) | — | |
| SCHEMBL11714837 | 0.80 | MTOR (0.37) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL11718023 | 0.80 | ABL1 (0.33) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4044130-A | ANIMAL FEED, 4-AMINO-3-5-NITRO-2-FURYL-1H-PYRAZOLO-3,4-D PYRIMIDINE N | CIBA-GEIGY CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |
| US-4044130-A | ANIMAL FEED, 4-AMINO-3-5-NITRO-2-FURYL-1H-PYRAZOLO-3,4-D PYRIMIDINE N | CIBA-GEIGY CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |
| US-4001230-A | ANTIBACTERIAL, ANTIPROTAZOAL | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3948913-A | PYRAZOLO(3,4-D)PYRIMIDINES; ANTIMICROBIAL | CIBA-GEIGY CORPORATION (US) | 1976-04-06 | — | — | US | disclosed |