Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HLCS | P50747 | 6/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | IDE | P14735 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 6/20 | 0.48 |
| ▸ | CA1 | P00915 | 6/20 | 0.48 |
| ▸ | CA2 | P00918 | 6/20 | 0.48 |
| ▸ | CA9 | Q16790 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16141168 | 0.95 | HLCS (0.97) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL6892318 | 0.94 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL6892316 | 0.94 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL14600958 | 0.94 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL12050323 | 0.94 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL16141170 | 0.94 | HLCS (1.00) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL17933966 | 0.83 | HLCS (0.91) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL13478399 | 0.83 | HLCS (0.91) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL12730079 | 0.83 | HLCS (0.91) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL10140318 | 0.83 | TDP1 (0.77) | HLCSTDP1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4009172-A | 2,3,3A,6,7,7A-Hexahydro-thieno[3,2-b]pyridin-(4H)5-ones | HOFFMANN-LA ROCHE INC. (US) | 1977-02-22 | — | — | US | disclosed |
| US-3957794-A | 3-Amino-2,3,3a,6,7,7a-hexahydro-thieno[3,2-b]pyridin-(4H)5-one | HOFFMANN-LA ROCHE INC. (US) | 1976-05-18 | — | — | US | disclosed |