HLCS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Biotin (SCHEMBL1270497)	0.48	7/20
SCHEMBL423924	1.00	6/20
SCHEMBL4813368	1.00	6/20
SCHEMBL4813371	1.00	6/20
SCHEMBL479231	0.82	6/20
Biotin (SCHEMBL6033491)	0.80	6/20
SCHEMBL93446	0.76	6/20
SCHEMBL771649	0.76	6/20
SCHEMBL5599921	0.76	6/20
Biotin (SCHEMBL3518095)	0.75	6/20
SCHEMBL2479213	0.73	6/20
SCHEMBL2537630	0.73	6/20
SCHEMBL2537631	0.73	6/20
SCHEMBL479444	0.72	6/20
Biotin (SCHEMBL987288)	0.72	6/20
Hexanoate (SCHEMBL4243024)	0.72	6/20
SCHEMBL4466074	0.72	6/20
SCHEMBL4320917	0.72	6/20
SCHEMBL2322596	0.71	6/20
Biotin (SCHEMBL715457)	0.70	6/20

Clinical trials — most relevant to HLCS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment	PHASE2	COMPLETED
Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease	PHASE1/PHASE2	RECRUITING
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Biotin-RBC Transfusion in SCD	PHASE1	COMPLETED
Q-Trial in Patients With Hepatitis C	PHASE1	COMPLETED
RBC Lifespan Measurement in Diabetic Children	PHASE1	COMPLETED
Clinical Study of CLL1 CAR-T Cells in the Treatment of Hematological Malignancies	EARLY_PHASE1	UNKNOWN
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Natural Course and Molecular Basis of Alpha 1- Antitrypsin Deficiency-associated Liver Disease.	nan	NOT_YET_RECRUITING
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment	nan	COMPLETED
The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease	nan	COMPLETED
Non-invasive Diagnosis of Pulmonary Embolism by Use of Biomarkers in Exhaled Breath Condensate	nan	COMPLETED
Effect of Mepolizumab on Severe Eosinophilic Asthma	nan	UNKNOWN
Genetic Variants in Linear Localized Scleroderma	nan	COMPLETED
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Gene x Behavior Interaction in the Look AHEAD Study	nan	COMPLETED
Genetic Markers of Coronary Heart Disease in Type 2 Diabetes	nan	COMPLETED
Non-invasive Prognostication of COVID-19 Patients by Use of Biomarkers in Exhaled Breath Condensate	nan	COMPLETED
Study of the Correlation Between Donor CIRBP and Transplanted Kidney Function	nan	COMPLETED
Demonstration of Carbonyl Stress on Hair Follicles	nan	COMPLETED
Expression of Altered Glycosyltransferases, Mucins, and RTKs in Human Ovarian and Endometrial Cancers	nan	UNKNOWN
Exhaled Breathing Condensate (EBC) Features and Lung Function Decline in Chinese Adults	nan	UNKNOWN
Histoblood Group Antigens as a Risk Factor of Asthma	nan	COMPLETED
Prevalence of fAmilial hypobetalipopRoTeinemIa in psychiaTrIc pOpulatioN (PARTITION)	nan	COMPLETED
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HLCS binder may also engage these)

Protein	Name	Similarity
Q920N2	—	0.997	Q920N2 →
Q8NFZ0	—	0.984	Q8NFZ0 →
Q6NYU2	—	0.979	Q6NYU2 →
Q496Y0	—	0.977	Q496Y0 →
P41214	—	0.976	P41214 →
Q2TBA3	—	0.976	Q2TBA3 →
P97616	—	0.975	P97616 →
A6QNT4	—	0.975	A6QNT4 →
Q14CH1	—	0.974	Q14CH1 →
P48553	—	0.973	P48553 →
Q8K2I9	—	0.972	Q8K2I9 →
B0KWQ2	—	0.972	B0KWQ2 →
F1ND48	—	0.971	F1ND48 →
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.971	landscape →
ABHD16A	Phosphatidylserine lipase ABHD16A	0.971	landscape →
Q66H91	—	0.971	Q66H91 →
Q9JI20	—	0.971	Q9JI20 →
TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1	0.971	landscape →
Q1LVW0	—	0.970	Q1LVW0 →
Q5R7L2	—	0.970	Q5R7L2 →
Q5MNU5	—	0.969	Q5MNU5 →
Q5XIJ6	—	0.969	Q5XIJ6 →
P97260	—	0.969	P97260 →
Q0V8R7	—	0.969	Q0V8R7 →
O43379	—	0.969	O43379 →
Q0IIH8	—	0.969	Q0IIH8 →
O35465	—	0.969	O35465 →
Q7TPQ3	—	0.969	Q7TPQ3 →
A2AWP8	—	0.969	A2AWP8 →
Q8BJQ9	—	0.968	Q8BJQ9 →