Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 6/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA3 | P07451 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA6 | P23280 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11722353 | 1.00 | CYP3A4 (0.46) | CYP3A4THRBTHRANPC1ALDH1A1 | |
| SCHEMBL135051 | 0.95 | CYP3A4 (0.48) | CYP3A4NPC1ALDH1A1RAB9ACA12 | |
| SCHEMBL21409331 | 0.93 | CYP3A4 (0.46) | CYP3A4NPC1ALDH1A1RAB9ACA1 | |
| SCHEMBL11563590 | 0.90 | CYP3A4 (0.50) | CYP3A4NPC1ALDH1A1RAB9ACA12 | |
| SCHEMBL134172 | 0.85 | CYP3A4 (0.54) | CYP3A4THRBNPC1ALDH1A1RAB9A | |
| SCHEMBL8539346 | 0.85 | CYP3A4 (0.54) | CYP3A4THRBNPC1ALDH1A1RAB9A | |
| SCHEMBL11492503 | 0.85 | THRB (0.36) | THRBTHRACA12CA1CA2 | |
| SCHEMBL11489030 | 0.85 | THRB (0.36) | THRBTHRACA12CA1CA2 | |
| SCHEMBL11486877 | 0.83 | THRB (0.34) | THRBTHRAALDH1A1RAB9ACA12 | |
| SCHEMBL11561919 | 0.80 | CYP3A4 (0.46) | CYP3A4THRBNPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4056382-A | THIADIAZOLYLUREA | ELI LILLY AND COMPANY (US) | 1977-11-01 | — | — | US | claimed |
| US-4056382-A | THIADIAZOLYLUREA | ELI LILLY AND COMPANY (US) | 1977-11-01 | — | — | US | disclosed |