Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.67 |
| ▸ | GAK | O14976 | 4/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.66 |
| ▸ | COQ8A | Q8NI60 | 4/20 | 0.66 |
| ▸ | NLK | Q9UBE8 | 4/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | TEK | Q02763 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172768 | 0.83 | IGF1R (0.64) | IGF1REGFRKDRINSRMET | |
| SCHEMBL1171995 | 0.81 | EPHB4 (0.59) | IGF1REGFRKDRINSRMET | |
| SCHEMBL1116462 | 0.81 | IGF1R (0.79) | IGF1REGFRKDRINSRMET | |
| SCHEMBL1172210 | 0.81 | IGF1R (0.61) | IGF1REGFRKDRINSRMET | |
| SCHEMBL1172205 | 0.81 | JAK2 (0.59) | IGF1RGAKRIPK2COQ8ANLK | |
| SCHEMBL1172054 | 0.81 | IGF1R (0.67) | IGF1REGFRKDRINSRMET | |
| SCHEMBL16129101 | 0.80 | IGF1R (0.69) | IGF1REGFRKDRINSRMET | |
| SCHEMBL30382491 | 0.80 | IGF1R (0.69) | IGF1REGFRKDRINSRMET | |
| SCHEMBL6981464 | 0.78 | IGF1R (0.78) | IGF1REGFRKDRINSRMET | |
| SCHEMBL26506659 | 0.77 | IGF1R (0.65) | IGF1REGFRKDRINSRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | EPHB4, EPHB1, EPHB3 | IGF1R 1124/4885GAK 529/4885RIPK2 3211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.