Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.78 |
| ▸ | CDK2 | P24941 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 2/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.73 |
| ▸ | INSR | P06213 | 1/20 | 0.73 |
| ▸ | MET | P08581 | 1/20 | 0.73 |
| ▸ | TEK | Q02763 | 1/20 | 0.73 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | PRKCG | P05129 | 2/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.66 |
| ▸ | CDK1 | P06493 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116462 | 0.93 | IGF1R (0.79) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL1116441 | 0.91 | IGF1R (0.76) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL6980742 | 0.88 | FAM20C (0.78) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL6976694 | 0.88 | EGFR (0.81) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL31180291 | 0.87 | IGF1R (0.71) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL6967800 | 0.87 | IGF1R (0.71) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL6976835 | 0.87 | IGF1R (0.78) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL1116426 | 0.87 | IGF1R (0.74) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL6980901 | 0.87 | IGF1R (0.70) | IGF1RCDK2KDREGFRINSR | |
| SCHEMBL1116439 | 0.87 | IGF1R (0.70) | IGF1RCDK2KDREGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |