Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11716756 | 0.95 | AKR1C3 (0.59) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL11719797 | 0.85 | AKR1C3 (0.45) | AKR1C3AKR1C2TSHRALDH1A1LMNA | |
| SCHEMBL14605797 | 0.85 | PTGS2 (0.46) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL9243075 | 0.84 | PTGS2 (0.62) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL11718787 | 0.84 | PTGS2 (0.62) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL10733997 | 0.84 | PTGS2 (0.62) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL11724960 | 0.84 | AKR1C3 (0.60) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL10729842 | 0.84 | PTGS2 (0.62) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL14606015 | 0.82 | AKR1C3 (0.49) | AKR1C3AKR1C2PTGS2TDP1L3MBTL1 | |
| SCHEMBL11716733 | 0.82 | PTGS2 (0.44) | AKR1C3AKR1C2PTGS2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4048330-A | Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia | SYNTEX CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |
| US-4009197-A | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof | SYNTEX CORPORATION (PM) | 1977-02-22 | — | — | US | disclosed |