SCHEMBL1172425

SCHEMBL1172425

Sc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.60
HPGD P15428 4/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
ALDH1A1 P00352 3/20 0.55
LMNA P02545 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
MAPK13 O15264 3/20 0.53
MAPK12 P53778 3/20 0.53
MAPK11 Q15759 3/20 0.53
MAPK14 Q16539 3/20 0.53
RAF1 P04049 2/20 0.53
MAPK9 P45984 1/20 0.53
GCGR P47871 1/20 0.51
MGAM O43451 1/20 0.50
KMT2A Q03164 2/20 0.49
MEN1 O00255 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
MAPT P10636 1/20 0.49
CYP2C9 P11712 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5445221 0.89 MAPK13 (0.60) KDM4EHPGDSMN1; SMN2ALDH1A1LMNA
SCHEMBL11382998 0.85 NOX1 (0.71) KDM4EHPGDSMN1; SMN2ALDH1A1LMNA
SCHEMBL11481381 0.84 NPY5R (0.48) KDM4EHPGDSMN1; SMN2ALDH1A1MAPK13
SCHEMBL9741082 0.84 NPY5R (0.51) KDM4EHPGDSMN1; SMN2ALDH1A1MAPK13
SCHEMBL9435546 0.82 MAPK13 (0.56) KDM4EHPGDALDH1A1LMNAMAPK13
SCHEMBL9741036 0.81 NPY5R (0.47) KDM4EHPGDSMN1; SMN2LMNAL3MBTL1
SCHEMBL5446798 0.80 GCGR (0.56) KDM4ELMNAL3MBTL1MAPK13MAPK12
SCHEMBL9666048 0.80 MAPK13 (0.49) KDM4EHPGDSMN1; SMN2ALDH1A1LMNA
SCHEMBL5435606 0.80 MAPK14 (0.56) KDM4EHPGDSMN1; SMN2ALDH1A1LMNA
SCHEMBL739928 0.78 MAPK13 (0.72) KDM4EHPGDSMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 453 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0680472-A1 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR PHARMACIA & UPJOHN S.p.A. (IT) 1995-11-08 EP claimed
WO-1995014673-A1 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR PHARMACIA S.P.A. (IT) 1995-06-01 WO claimed
EP-0352123-B1 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use UBE INDUSTRIES (JP) 1995-01-18 EP claimed
WO-1992015562-A2 PREPARATION OF OMEGA-SUBSTITUTED ALKANAMIDE EASTMAN KODAK COMPANY (US) 1992-09-17 WO claimed
EP-0442448-A2 Heterocyclic carboxylic acids and esters Bristol-Myers Squibb Company (US) 1991-08-21 EP claimed
US-6423486-B1 None US disclosed
JP-7149733-A None JP disclosed
CN-120136899-A Azo/deuterated imidazothiazinone compound, synthetic method and application 新疆大学 2025-06-13 CN disclosed
CN-120153320-A Colored curable resin composition, color filter, display device, and solid-state imaging element 住友化学株式会社 2025-06-13 CN disclosed
CN-111344359-B Blue curable resin composition, blue color filter, and display device including the blue color filter 住友化学株式会社 2024-10-22 CN disclosed
WO-2024190525-A1 COLORED CURABLE RESIN COMPOSITION, OPTICAL FILTER, AND SOLID-STATE IMAGING ELEMENT 住友化学株式会社 2024-09-19 WO disclosed
WO-2024190526-A1 COLORED CURABLE RESIN COMPOSITION, OPTICAL FILTER, AND SOLID-STATE IMAGING ELEMENT 住友化学株式会社 2024-09-19 WO disclosed
US-4528298-A Antiinflammatory imidazole derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1985-07-09 US disclosed
US-4402960-A Antiinflammatory imidazole derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1983-09-06 US disclosed
EP-0059090-A1 3,5-Di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1982-09-01 EP disclosed
US-4330552-A Antiinflammatory 4,5-diaryl-2-arylthioimidazoles E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-05-18 US disclosed
EP-0043788-A1 Imidazole derivatives, process for their preparation and their pharmaceutical compositions SCHERING AKTIENGESELLSCHAFT (DE) 1982-01-13 EP disclosed
US-4263311-A ANTIARTHRITIC AGENTS SMITHKLINE CORPORATION (US) 1981-04-21 US disclosed
US-4190666-A ANTIARTHRITIC, ANALGESIC E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-02-26 US disclosed
US-3976769-A INSECTICIDE AIRWICK INDUSTRIES, INC. (US) 1976-08-24 US disclosed