Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 18/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 18/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 18/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.56 |
| ▸ | RAF1 | P04049 | 5/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.56 |
| ▸ | GCGR | P47871 | 13/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | FRK | P42685 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098384 | 0.90 | MAPK14 (0.69) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL4285506 | 0.90 | MAPK14 (0.69) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL9340175 | 0.86 | MAPK14 (0.65) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL9339561 | 0.86 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL1172425 | 0.82 | KDM4E (0.60) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5446798 | 0.78 | GCGR (0.56) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL7300360 | 0.78 | NPY5R (0.39) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5435606 | 0.78 | MAPK14 (0.56) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL9666048 | 0.78 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL5445232 | 0.78 | MAPK13 (0.55) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | claimed |
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |