Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297782 | 1.00 | IGF1R (0.73) | IGF1RALDH1A1KCNJ1KCNH2HTR1A | |
| SCHEMBL1353999 | 0.92 | IGF1R (0.64) | IGF1RALDH1A1KCNJ1KCNH2HTR1A | |
| SCHEMBL286837 | 0.89 | KCNJ1 (0.73) | IGF1RKCNJ1KCNH2HTR1AHTR2A | |
| SCHEMBL4477546 | 0.88 | KDM4E (0.70) | IGF1RALDH1A1HTR1ASMN1; SMN2HTR2A | |
| SCHEMBL27959969 | 0.85 | IGF1R (1.00) | IGF1RALDH1A1HTR1AMEN1KMT2A | |
| SCHEMBL9515064 | 0.85 | IGF1R (0.74) | IGF1RALDH1A1HTR1AMEN1KMT2A | |
| SCHEMBL4475769 | 0.85 | KDM4E (0.70) | IGF1RALDH1A1HTR1ANPC1SMN1; SMN2 | |
| SCHEMBL4483824 | 0.85 | KDM4E (0.70) | IGF1RALDH1A1HTR1ANPC1SMN1; SMN2 | |
| SCHEMBL4478168 | 0.85 | KDM4E (0.70) | IGF1RALDH1A1HTR1ANPC1SMN1; SMN2 | |
| SCHEMBL4470929 | 0.84 | IGF1R (0.57) | IGF1RKCNJ1KCNH2HTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4059588-A | RING CLOSURE | ICI AUSTRALIA LIMITED (AU) | 1977-11-22 | — | — | US | disclosed |