Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297782 | 0.85 | IGF1R (0.73) | IGF1RHTR1AKMT2AMEN1TDP1 | |
| SCHEMBL11726331 | 0.85 | IGF1R (0.73) | IGF1RHTR1AKMT2AMEN1TDP1 | |
| SCHEMBL27959969 | 0.85 | IGF1R (1.00) | IGF1RHTR1AKMT2AMEN1TDP1 | |
| SCHEMBL9513747 | 0.81 | KMT2A (0.53) | IGF1RHTR1ASPHK1KMT2AMEN1 | |
| SCHEMBL9513530 | 0.81 | KMT2A (0.58) | IGF1RHTR1ASPHK1KMT2AMEN1 | |
| SCHEMBL3439980 | 0.80 | POLB (0.73) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1353999 | 0.79 | IGF1R (0.64) | IGF1RHTR1AKMT2AMEN1TDP1 | |
| SCHEMBL9514826 | 0.78 | POLB (0.90) | POLBALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL10580775 | 0.78 | SPHK1 (0.55) | IGF1RHTR1ASPHK1KMT2AMEN1 | |
| SCHEMBL519460 | 0.77 | IGF1R (0.65) | IGF1RPOLBHTR1ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |