Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380 | 0.87 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL14322009 | 0.81 | BACE1 (0.59) | BACE1CTSD | |
| SCHEMBL14322010 | 0.72 | BACE1 (0.58) | BACE1CTSD | |
| SCHEMBL14322439 | 0.72 | BACE1 (0.58) | BACE1CTSD | |
| SCHEMBL11417 | 0.72 | BACE1 (0.58) | BACE1CTSD | |
| SCHEMBL13756 | 0.72 | BACE1 (0.71) | BACE1CTSD | |
| SCHEMBL14321792 | 0.70 | BACE1 (0.55) | BACE1CTSD | |
| SCHEMBL17620371 | 0.69 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL9288 | 0.69 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL17620296 | 0.67 | BACE1 (1.00) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |