Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 9/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11724446 | 0.89 | METAP1 (0.72) | METAP1THRATHRBCYP3A4SMN1; SMN2 | |
| SCHEMBL10858599 | 0.83 | METAP1 (0.60) | METAP1THRATHRB | |
| SCHEMBL11725306 | 0.83 | METAP1 (0.51) | METAP1THRATHRB | |
| Hydrochloric Acid SCHEMBL11728965 | 0.82 | METAP1 (0.53) | METAP1THRATHRB | |
| Hydrochloric Acid SCHEMBL10853732 | 0.82 | METAP1 (0.63) | METAP1THRATHRB | |
| SCHEMBL11011369 | 0.82 | METAP1 (0.76) | METAP1THRATHRB | |
| Hydrochloric Acid SCHEMBL4623159 | 0.81 | METAP1 (0.78) | METAP1THRATHRB | |
| SCHEMBL8003063 | 0.79 | METAP1 (0.71) | METAP1THRATHRB | |
| SCHEMBL2125675 | 0.79 | METAP1 (0.71) | METAP1THRATHRB | |
| Iodide SCHEMBL9134076 | 0.79 | CYP19A1 (0.40) | METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051248-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, NEUROLEPTIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-09-27 | — | — | US | disclosed |