Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 7/20 | 0.76 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.71 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.71 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.71 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.71 |
| ▸ | BRD4 | O60885 | 2/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23881599 | 0.90 | PTAFR (0.63) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11620188 | 0.89 | PTAFR (0.79) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL14282558 | 0.89 | PTAFR (0.79) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11858842 | 0.88 | PTAFR (0.65) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL2841164 | 0.87 | GABRA1 (0.76) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11185785 | 0.87 | PTAFR (0.76) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL7327360 | 0.87 | GABRA1 (0.79) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL9378631 | 0.87 | PTAFR (1.00) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11395828 | 0.87 | PTAFR (0.66) | PTAFRGABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL29858197 | 0.87 | GABRA1 (0.76) | PTAFRGABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4018788-A | 6-(O-Halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine | THE UPJOHN COMPANY (US) | 1977-04-19 | — | — | US | disclosed |