⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117310 | 1.00 | — | — | |
| SCHEMBL10069519 | 0.76 | — | — | |
| SCHEMBL10069518 | 0.75 | — | — | |
| SCHEMBL10069517 | 0.75 | — | — | |
| SCHEMBL118375 | 0.73 | — | — | |
| SCHEMBL117305 | 0.73 | — | — | |
| SCHEMBL117303 | 0.72 | — | — | |
| SCHEMBL8239269 | 0.66 | RAB9A (0.53) | — | |
| SCHEMBL8948422 | 0.62 | NPC1 (0.71) | — | |
| SCHEMBL28459613 | 0.60 | POLB (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |