Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11738956 | 0.93 | MAPKAPK2 (0.70) | MAPKAPK2EPHX2GAKMKNK1MKNK2 | |
| SCHEMBL7346130 | 0.91 | PDGFRB (0.51) | MAPKAPK2GAKDHFRNAMPTABL1 | |
| SCHEMBL11736021 | 0.91 | HPGD (0.52) | MAPKAPK2GAKDHFRHPGD | |
| SCHEMBL11730683 | 0.90 | MAPKAPK2 (0.64) | MAPKAPK2EPHX2RAD52GFERABL1 | |
| SCHEMBL11742317 | 0.90 | HPGD (0.54) | MAPKAPK2GAKDHFRHPGD | |
| Hydrochloric Acid SCHEMBL11735242 | 0.89 | HPGD (0.53) | MAPKAPK2GAKDHFRHPGD | |
| SCHEMBL11543560 | 0.89 | KDM4E (0.58) | MAPKAPK2EPHX2NAMPT | |
| SCHEMBL11735756 | 0.89 | DHFR (0.53) | MAPKAPK2EPHX2GAKDHFR | |
| SCHEMBL11739356 | 0.88 | MAPKAPK2 (0.49) | MAPKAPK2EPHX2GAKDHFR | |
| SCHEMBL7372028 | 0.88 | MKNK2 (0.52) | MAPKAPK2GAKMKNK1MKNK2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4025629-A | HYPOTENSIVES, ANTIANXIETY | THE UPJOHN COMPANY (US) | 1977-05-24 | — | — | US | claimed |
| US-4025629-A | HYPOTENSIVES, ANTIANXIETY | THE UPJOHN COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-4025629-A | HYPOTENSIVES, ANTIANXIETY | THE UPJOHN COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-3992382-A | HYPERTENSION AND ANXIETY TREATMENT | THE UPJOHN COMPANY (US) | 1976-11-16 | — | — | US | disclosed |