Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 15/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725233 | 0.91 | SIRT1 (0.64) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL4726705 | 0.86 | SIRT1 (0.59) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL4726038 | 0.84 | SIRT1 (0.59) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL1872225 | 0.81 | SIRT1 (1.00) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL1674922 | 0.81 | SIRT1 (0.79) | SIRT1SIRT2SIRT3MEN1KMT2A | |
| SCHEMBL1875568 | 0.81 | SIRT1 (0.64) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL4728208 | 0.79 | SIRT1 (0.73) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL11738069 | 0.79 | SIRT1 (0.56) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL4726880 | 0.78 | MEN1 (0.76) | SIRT1SIRT2SIRT3RECQLMEN1 | |
| SCHEMBL1873883 | 0.76 | SIRT1 (0.79) | SIRT1SIRT2SIRT3RECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4057640-A | ANTIINFLAMMATORY | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-11-08 | — | — | US | disclosed |
| US-3956295-A | ANTIINFLAMMATORY | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-05-11 | — | — | US | disclosed |