Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.73 |
| ▸ | OPRL1 | P41146 | 17/20 | 0.73 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 16/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11745286 | 0.98 | OPRM1 (0.71) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL9520650 | 0.84 | OPRL1 (1.00) | OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL2962625 | 0.82 | OPRM1 (0.65) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL7239736 | 0.80 | CYP2D6 (0.64) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL8916036 | 0.79 | CYP1A2 (0.62) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL30363975 | 0.79 | OPRM1 (0.61) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL1964502 | 0.79 | CYP1A2 (0.62) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL30364119 | 0.79 | OPRM1 (0.61) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL8922757 | 0.78 | CYP1A2 (0.66) | OPRM1OPRL1OPRD1OPRK1CYP2D6 | |
| SCHEMBL4334322 | 0.78 | CYP1A2 (0.66) | OPRM1OPRL1OPRD1OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4022786-A | PHARMACEUTICALS, CNS STIMULANT | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) | 1977-05-10 | — | — | US | disclosed |
| US-4016280-A | 4,4-Diarylpiperidine compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) | 1977-04-05 | — | — | US | disclosed |