Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.64 |
| ▸ | PGR | P06401 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | PTGIR | P43119 | 7/20 | 0.58 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11658243 | 1.00 | LMNA (0.64) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11660350 | 1.00 | LMNA (0.64) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11792744 | 0.91 | LMNA (0.73) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11787857 | 0.91 | LMNA (0.73) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11789598 | 0.91 | LMNA (0.73) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11792739 | 0.91 | LMNA (0.73) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11786650 | 0.91 | LMNA (0.73) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11794793 | 0.90 | LMNA (0.74) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11787294 | 0.90 | LMNA (0.74) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL11791791 | 0.90 | LMNA (0.74) | LMNAABCC4PGRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4005106-A | 3β-[(Methoxalyl)oxy]-2α-(3-oxo-1-octenyl)-5-oxo-1β-cyclopentaneheptanoic acid and process | MERCK & CO., INC. (US) | 1977-01-25 | — | — | US | disclosed |
| US-3998849-A | 2α-(2-Carboxy-2-formylethyl)-3β-hydroxy-5-oxo-β-cyclopentaneheptanoic acid and process | MERCK & CO., INC. (US) | 1976-12-21 | — | — | US | disclosed |
| US-3992412-A | 2α-(2-Carboxy-2-oxoethyl)-3β-hydroxy-5-oxo-1β-cyclopentaneheptanoic acid and process | MERCK & CO., INC. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3991083-A | 2α-(2-Loweralkanoyloxy-2-carboxyvinyl)-3β-hydroxy-5-oxo-1β-c | MERCK & CO., INC. (US) | 1976-11-09 | — | — | US | disclosed |