Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.41 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11753364 | 0.79 | CHEK1 (0.47) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11748758 | 0.79 | CHEK1 (0.47) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11751390 | 0.79 | CSNK1G1 (0.62) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11744445 | 0.76 | LRRK2 (0.40) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11535564 | 0.76 | LRRK2 (0.40) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11634099 | 0.76 | CHEK1 (0.62) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11529475 | 0.76 | CHEK1 (0.62) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL11557784 | 0.76 | CHEK1 (0.47) | CSNK1G1ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL9094147 | 0.76 | ACVR1 (0.61) | PTGS2CSNK1G1ROS1CDK5ACVR1 | |
| SCHEMBL11747469 | 0.75 | ALDH1A1 (0.53) | CSNK1G1LRRK2CHEK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4007272-A | Substituted benzodiazepin-10-ones in treating pain and depression | AMERICAN CYANAMID COMPANY (US) | 1977-02-08 | — | — | US | disclosed |
| US-3953430-A | ANTIDEPRESSANTS, ANALGESICS | AMERICAN CYANAMID COMPANY (US) | 1976-04-27 | — | — | US | disclosed |