Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11749061 | 1.00 | MEN1 (0.53) | MEN1KMT2ARAD52DRD1HTR1A | |
| SCHEMBL11749707 | 0.84 | DRD1 (0.56) | KMT2ARAD52DRD1HTR1ADRD2 | |
| SCHEMBL11749701 | 0.84 | DRD1 (0.56) | KMT2ARAD52DRD1HTR1ADRD2 | |
| SCHEMBL16627026 | 0.80 | DRD1 (0.53) | DRD1TRPV1CA1CA2CA9 | |
| SCHEMBL16627024 | 0.80 | DRD1 (0.53) | DRD1TRPV1CA1CA2CA9 | |
| SCHEMBL11705438 | 0.78 | GRIN2C (0.55) | RAD52DRD1HTR1ADRD2KCNH2 | |
| SCHEMBL15610205 | 0.78 | RAD52 (0.61) | RAD52DRD1HTR1ADRD2 | |
| SCHEMBL14234700 | 0.78 | RAD52 (0.61) | RAD52DRD1HTR1ADRD2 | |
| SCHEMBL15610096 | 0.78 | RAD52 (0.61) | RAD52DRD1HTR1ADRD2 | |
| SCHEMBL9617443 | 0.78 | RAD52 (0.61) | RAD52DRD1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4013666-A | (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto | G. D. SEARLE & CO. (US) | 1977-03-22 | — | — | US | disclosed |