Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 9/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15610205 | 1.00 | RAD52 (0.61) | RAD52MAOASMN1; SMN2DRD1CA7 | |
| SCHEMBL15610096 | 1.00 | RAD52 (0.61) | RAD52MAOASMN1; SMN2DRD1CA7 | |
| SCHEMBL14234700 | 1.00 | RAD52 (0.61) | RAD52MAOASMN1; SMN2DRD1CA7 | |
| SCHEMBL14234697 | 1.00 | RAD52 (0.61) | RAD52MAOASMN1; SMN2DRD1CA7 | |
| SCHEMBL14234719 | 0.92 | DRD2 (0.64) | RAD52MAOASMN1; SMN2DRD1DRD2 | |
| SCHEMBL14235282 | 0.92 | DRD2 (0.64) | RAD52MAOASMN1; SMN2DRD1DRD2 | |
| SCHEMBL14234720 | 0.92 | DRD2 (0.64) | RAD52MAOASMN1; SMN2DRD1DRD2 | |
| SCHEMBL15611358 | 0.89 | DRD1 (0.57) | RAD52DRD1DRD2HTR1A | |
| SCHEMBL14235260 | 0.89 | DRD1 (0.57) | RAD52DRD1DRD2HTR1A | |
| SCHEMBL14235259 | 0.84 | DRD1 (0.59) | RAD52MAOADRD1DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4036239-A | — | — | None | — | — | JP | disclosed |
| JP-H0436239-A | ANTI-HBV AGENT | FUJIREBIO INC | 1992-02-06 | — | — | JP | disclosed |
| EP-0108147-B1 | USE OF A PROTOBERBERINE ALKALOID AND COMPOSITION CONTAINING SAME | MAROKO, Peter R. (US) | 1988-08-17 | — | — | EP | disclosed |
| EP-0108147-A4 | Use of a protoberberine alkaloid and composition containing same. | MAROKO PETER R | 1984-09-13 | — | — | EP | disclosed |
| EP-0108147-A1 | Use of a protoberberine alkaloid and composition containing same. | MAROKO PETER R | 1984-05-16 | — | — | EP | disclosed |
| WO-1983003970-A1 | COMPOUNDS, COMPOSITIONS AND METHOD OF TREATMENT FOR IMPROVING CIRCULATORY PERFORMANCE | MAROKO PETER R | 1983-11-24 | — | — | WO | disclosed |