Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | RXRB | P28702 | 4/20 | 0.36 |
| ▸ | RXRG | P48443 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.33 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754514 | 0.93 | NR4A2 (0.50) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11753895 | 0.93 | NR4A2 (0.50) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11752390 | 0.84 | RXRA (0.48) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11752484 | 0.81 | RXRA (0.46) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11753348 | 0.81 | NR4A2 (0.47) | NR4A2RXRARXRBRXRGPTGS2 | |
| SCHEMBL11753577 | 0.81 | MEN1 (0.40) | NR4A2RXRARXRBRXRGCNR1 | |
| SCHEMBL11751989 | 0.81 | MAPK14 (0.50) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6025571 | 0.80 | NR4A2 (0.60) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11750796 | 0.78 | NOTUM (0.39) | NR4A2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL11754360 | 0.78 | RXRA (0.57) | NR4A2MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051250-A | OXAZOLE, THIAZOLE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |
| US-3933840-A | ANTIPHLOGISTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1976-01-20 | — | — | US | disclosed |