RXRA

Retinoic acid receptor RXR-alpha · P19793 · RXRA on Sugi Atlas →

193,897 patent compounds predicted against RXRA, 98,608 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Bexarotene (SCHEMBL9025)	1.00	20/20
Oxaprozin (SCHEMBL3286)	1.00	19/20
SCHEMBL110818	0.42	18/20
SCHEMBL112943	0.63	15/20
(+)-Abscisic Acid (SCHEMBL33612)	0.42	13/20
(+)-Abscisic Acid (SCHEMBL33613)	0.42	13/20
Abscisic Acid (SCHEMBL33614)	0.42	13/20
Acitretin (SCHEMBL3759)	0.45	12/20
Tamibarotene (SCHEMBL36207)	0.62	11/20
SCHEMBL88554	0.50	8/20
SCHEMBL100476	0.54	7/20
SCHEMBL76093	0.50	7/20
SCHEMBL108958	0.44	7/20
SCHEMBL61333	0.36	7/20
Exisulind (SCHEMBL25371)	0.74	6/20
Sulindac (SCHEMBL4202)	0.73	6/20
Sulindac (SCHEMBL4203)	0.73	6/20
Sulindac (SCHEMBL80209)	0.71	6/20
SCHEMBL69066	0.63	6/20
SCHEMBL78581	0.50	6/20

Clinical trials — most relevant to RXRA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis	PHASE2/PHASE3	COMPLETED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)	PHASE3	UNKNOWN
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia	PHASE3	COMPLETED
Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma	PHASE3	COMPLETED
Oral NRX 194204 Study in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)	PHASE2	UNKNOWN
Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.	PHASE1/PHASE2	UNKNOWN
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment	PHASE2	UNKNOWN
Efatutazone Dihydrochloride in Treating Patients With Previously Treated Myxoid Liposarcoma That Cannot Be Removed by Surgery	PHASE2	COMPLETED
Study of Oral Bexarotene in Combination With Photopheresis for Treatment of Cutaneous T-Cell Lymphoma	PHASE1/PHASE2	COMPLETED
Efficacy of Docosahexaenoic Acid on Tardive Dyskinesia	PHASE2	WITHDRAWN
Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)	PHASE2	COMPLETED
Efficacy and Safety of Tamibarotene(AM80) for Lupus Nephritis	PHASE2	UNKNOWN
TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)	PHASE2	COMPLETED
Effect of All-trans Retinoic Acid With Chemotherapy Based in Paclitaxel and Cisplatin as First Line Treatment of Patients With Advanced Non-small Cell Lung Cancer	PHASE2	COMPLETED
Pembrolizumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma	PHASE1/PHASE2	COMPLETED
Lymphocyte Support to SBRT in Patients With Oligo-metastatic Solid Cancer	PHASE1/PHASE2	RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19	PHASE2	UNKNOWN
Belinostat and Isotretinoin in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery	PHASE1	COMPLETED
Treatment of Acute Myeloid Leukemia With Arsenic and All-trans Retinoid Acid	PHASE1	UNKNOWN
A Clinical Trial for the Safety and Efficacy of CD-801 in Patients With Advanced Hepatocellular Carcinoma	EARLY_PHASE1	COMPLETED
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous CD-801 in Treating Advanced HCC Patients	EARLY_PHASE1	RECRUITING
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes	nan	COMPLETED
RORC Genetic Polymorphism of Rheumatoid Arthritis	nan	COMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Retinoic Acid Homeostasis in Neuropsychiatric Diseases	nan	UNKNOWN
PPAR, RXR, and VDR Expressions in Diabetes	nan	COMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer	nan	COMPLETED
Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a RXRA binder may also engage these)

Protein	Name	Similarity
P28700	—	1.000	P28700 →
P51128	—	1.000	P51128 →
Q05343	—	1.000	Q05343 →
A2T929	—	1.000	A2T929 →
Q90416	—	1.000	Q90416 →
P51129	—	1.000	P51129 →
Q5REL6	—	1.000	Q5REL6 →
Q0VC20	—	1.000	Q0VC20 →
Q5BJR8	—	1.000	Q5BJR8 →
Q7SYN5	—	1.000	Q7SYN5 →
Q8T5C6	—	1.000	Q8T5C6 →
P28701	—	1.000	P28701 →
Q6DHP9	—	1.000	Q6DHP9 →
Q5I7G2	—	1.000	Q5I7G2 →
P28705	—	1.000	P28705 →
Q0GFF6	—	1.000	Q0GFF6 →
RXRG	Retinoic acid receptor RXR-gamma	1.000	landscape →
Q64249	—	0.999	Q64249 →
P33242	—	0.999	P33242 →
P50569	—	0.999	P50569 →
ESRRB	Steroid hormone receptor ERR2	0.999	landscape →
P22449	—	0.999	P22449 →
Q90415	—	0.999	Q90415 →
Q5RAM2	—	0.999	Q5RAM2 →
P45448	—	0.999	P45448 →
P31396	—	0.999	P31396 →
Q90417	—	0.999	Q90417 →
Q14541	—	0.999	Q14541 →
Q66JK1	—	0.998	Q66JK1 →
F1QLY4	—	0.998	F1QLY4 →