SCHEMBL11754136

SCHEMBL11754136

OCCCSc1nc(-c2ccccc2)c(-c2ccccc2)o1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.69
CYP1A2 P05177 1/20 0.69
CYP2C19 P33261 1/20 0.69
POLB P06746 4/20 0.64
HRH3 Q9Y5N1 1/20 0.63
GAA P10253 2/20 0.60
ALDH1A1 P00352 6/20 0.58
KDM4E B2RXH2 4/20 0.58
ALOX15 P16050 2/20 0.58
TSHR P16473 2/20 0.58
MAPK1 P28482 1/20 0.58
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
HPGD P15428 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
LMNA P02545 3/20 0.49
MAPT P10636 2/20 0.49
NR4A2 P43354 3/20 0.46
NR4A1 P22736 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11756174 0.96 HSD17B10 (0.68) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11752973 0.94 HSD17B10 (0.66) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL10842982 0.91 HSD17B10 (0.73) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11750129 0.86 HSD17B10 (0.51) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11708956 0.85 HSD17B10 (0.69) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11753276 0.85 HSD17B10 (0.64) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11749942 0.83 GAA (0.74) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL9452973 0.82 HSD17B10 (0.61) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11750639 0.82 HSD17B10 (0.61) HSD17B10CYP1A2CYP2C19POLBHRH3
SCHEMBL11753339 0.82 HSD17B10 (0.64) HSD17B10CYP1A2CYP2C19POLBHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4051250-A OXAZOLE, THIAZOLE MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-09-27 US disclosed
US-3933840-A ANTIPHLOGISTIC MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-01-20 US disclosed