Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 8/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11823008 | 0.82 | NPC1L1 (0.52) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL13988168 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL15107562 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL14007452 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL131383 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL14005008 | 0.80 | NPC1L1 (0.45) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL10821098 | 0.80 | NPC1L1 (0.43) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL10821097 | 0.80 | NPC1L1 (0.43) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL15694753 | 0.78 | NPC1L1 (0.56) | NPC1L1USP2TP53MEN1LMNA | |
| SCHEMBL11125990 | 0.78 | NPC1L1 (0.56) | NPC1L1USP2TP53MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4038272-A | STEREOSPECIFIC SYNTHESES OF 24R,25- AND 24S,25-DIHYDROXYCHOLESTEROL AND ALKANOYL DERIVATIVES THEREOF | HOFFMANN-LA ROCHE INC. (US) | 1977-07-26 | — | — | US | disclosed |