Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 6/20 | 0.52 |
| ▸ | USP2 | O75604 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967993 | 0.89 | RORC (0.48) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL12917608 | 0.89 | RORC (0.48) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL12947553 | 0.89 | RORC (0.48) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL22646215 | 0.89 | RORC (0.48) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL11823290 | 0.89 | RORC (0.48) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL13988168 | 0.86 | NPC1L1 (0.70) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL14007452 | 0.86 | NPC1L1 (0.70) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL131383 | 0.86 | NPC1L1 (0.70) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL15107562 | 0.86 | NPC1L1 (0.70) | NPC1L1USP2TP53LMNAMEN1 | |
| SCHEMBL11755500 | 0.82 | NPC1L1 (0.48) | NPC1L1USP2TP53LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3994878-A | Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof | HOFFMANN-LA ROCHE INC. (US) | 1976-11-30 | — | — | US | disclosed |