Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11334878 | 0.89 | AKR1B1 (0.59) | AKR1B1MAPK14TP53MAPTPTGS2 | |
| SCHEMBL11754943 | 0.85 | AKR1B1 (0.55) | AKR1B1MAPK14TP53MAPTPTGS2 | |
| SCHEMBL11840294 | 0.82 | AKR1B1 (0.57) | AKR1B1MAPK14TP53MAPTPTGS2 | |
| SCHEMBL11843928 | 0.81 | AKR1B1 (0.53) | AKR1B1MAPK14PTGS2OPRK1PDE4D | |
| SCHEMBL11820011 | 0.80 | AKR1B1 (0.51) | AKR1B1MAPK14TP53MAPTPTGS2 | |
| SCHEMBL11655197 | 0.80 | AKR1B1 (0.51) | AKR1B1MAPK14TP53MAPTOPRK1 | |
| SCHEMBL11824137 | 0.80 | AKR1B1 (0.54) | AKR1B1MAPK14MAPTPTGS2OPRK1 | |
| SCHEMBL11741137 | 0.80 | AKR1B1 (0.49) | AKR1B1MAPK14TP53MAPTPTGS2 | |
| SCHEMBL11846414 | 0.79 | AKR1B1 (0.54) | AKR1B1MAPK14TP53MAPTACHE | |
| SCHEMBL11849936 | 0.79 | AKR1B1 (0.54) | AKR1B1MAPK14TP53MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4055574-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, MUSCLE RELAXANT | SYNTEX (U.S.A.) INC. (US) | 1977-10-25 | — | — | US | disclosed |
| US-4000308-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000288-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, PYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |