SCHEMBL11760199

SCHEMBL11760199

C=CCN(CC#N)c1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-]

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 5/20 0.53
CYP3A4 P08684 3/20 0.53
TSHR P16473 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
MAPT P10636 5/20 0.49
GAA P10253 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
ALDH1A1 P00352 4/20 0.42
HPGD P15428 1/20 0.42
ALOX15 P16050 1/20 0.42
HIF1A Q16665 1/20 0.42
TXNRD1 Q16881 1/20 0.42
TXNRD3 Q86VQ6 1/20 0.42
TXNRD2 Q9NNW7 1/20 0.42
PLK1 P53350 2/20 0.39
PTPN5 P54829 1/20 0.37
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
POLB P06746 2/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11201388 0.88 MAPK1 (0.62) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11765814 0.88 MAPK1 (0.54) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11763436 0.83 MAPK1 (0.36) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11205360 0.83 CYP3A4 (0.66) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11759482 0.81 MAPK1 (0.78) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11758464 0.81 MAPK1 (0.58) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11763305 0.81 CYP3A4 (0.58) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL11522680 0.78 MAPK1 (0.54) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL8153584 0.78 MAPK1 (0.51) MAPK1CYP3A4TSHRTDP1MAPT
SCHEMBL9345956 0.78 CYP3A4 (0.56) MAPK1CYP3A4TSHRTDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4042628-A HERBICIDES BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1977-08-16 US disclosed