Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24059005 | 0.84 | HRH3 (0.38) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL11753821 | 0.81 | HRH3 (0.39) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL11761485 | 0.79 | PGK1 (0.41) | — | |
| SCHEMBL20843313 | 0.73 | HRH3 (0.34) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL26257572 | 0.72 | MEN1 (0.38) | HRH3RAPGEF4MEN1MAPK1KMT2A | |
| SCHEMBL27995904 | 0.71 | HRH3 (0.54) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL1316919 | 0.71 | HTR1D (0.48) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL24058996 | 0.71 | KMT2A (0.39) | MEN1MAPK1KMT2AKDM4EALDH1A1 | |
| SCHEMBL327084 | 0.69 | HRH3 (0.41) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL28489168 | 0.69 | HRH3 (0.41) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4061681-A | Method for the preparation of mono- or poly [dialkyl or dicycloalkylphosphonylmethyl] aromatic carbocyclic compounds | AMERICAN CYANAMID COMPANY (US) | 1977-12-06 | — | — | US | disclosed |