Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11765230 | 0.88 | LCK (0.40) | PPARGRXRAMAPTEGFRLCK | |
| SCHEMBL11762113 | 0.87 | RXRA (0.46) | PPARGRXRAPTGS1LCK | |
| SCHEMBL11763195 | 0.87 | PPARG (0.58) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL11766747 | 0.85 | MDM2 (0.39) | PPARGRXRAPSEN1PSEN2APH1B | |
| SCHEMBL11764897 | 0.84 | PPARG (0.49) | PPARGNFE2L2RXRACYP1A2MAPT | |
| SCHEMBL11759595 | 0.83 | LCK (0.36) | PPARGRXRALCK | |
| SCHEMBL11765885 | 0.82 | TLR9 (0.45) | NFE2L2MAPTPTGS2TDP1PTGS1 | |
| SCHEMBL11765459 | 0.82 | PPARG (0.47) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL11767110 | 0.80 | PPARG (0.50) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL11763889 | 0.80 | PPARG (0.50) | PPARGRXRACYP1A2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4061771-A | Ethynylindenyl compounds and derivatives thereof used in the treatment of pain, fever and inflammation | WILLIAM H. RORER, INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-3983253-A | Ethynylindenyl compounds and derivatives thereof used in the treatment of pain, fever and inflammation | WILLIAM H. RORER, INC. (US) | 1976-09-28 | — | — | US | disclosed |