Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL11340733 | 0.91 | TSHR (0.42) | TSHRCYP3A4MEN1KMT2ASLC1A2 | |
| Bicarbonate SCHEMBL2169350 | 0.87 | TSHR (0.45) | TSHRCYP3A4MEN1KMT2ASLC1A2 | |
| Bicarbonate SCHEMBL9835481 | 0.87 | TSHR (0.45) | TSHRCYP3A4MEN1KMT2ASLC1A2 | |
| SCHEMBL851045 | 0.87 | — | — | |
| SCHEMBL7454479 | 0.84 | TSHR (0.56) | TSHRCYP3A4ALDH1A1TDP1MAPT | |
| Bicarbonate SCHEMBL11744374 | 0.84 | TSHR (0.43) | TSHRMEN1KMT2ASLC1A2ALDH1A1 | |
| SCHEMBL850797 | 0.84 | — | — | |
| SCHEMBL11225741 | 0.84 | — | — | |
| SCHEMBL14351852 | 0.84 | TSHR (0.56) | TSHRCYP3A4ALDH1A1TDP1MAPT | |
| Bicarbonate SCHEMBL4954542 | 0.81 | TSHR (0.41) | TSHRCYP3A4MEN1KMT2ASLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3946014-A | Process for preparing certain 1,3,4-dioxazol-2-ones and products | ATLANTIC RICHFIELD COMPANY (US) | 1976-03-23 | — | — | US | disclosed |