Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179446 | 0.87 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPK1RAB9APKM | |
| SCHEMBL28633815 | 0.85 | ALDH1A1 (0.72) | ALDH1A1LMNAMAPK1NPC1RAB9A | |
| SCHEMBL1180961 | 0.83 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPK1NPC1RAB9A | |
| SCHEMBL1179795 | 0.78 | EGFR (0.49) | ALDH1A1LMNAMAPK1NPC1RAB9A | |
| SCHEMBL1180475 | 0.76 | EGFR (0.48) | ALDH1A1LMNAMAPK1RAB9APKM | |
| SCHEMBL30666441 | 0.76 | NPC1 (0.74) | ALDH1A1LMNAMAPK1NPC1RAB9A | |
| SCHEMBL29128053 | 0.76 | NPC1 (0.74) | ALDH1A1LMNAMAPK1NPC1RAB9A | |
| SCHEMBL4713821 | 0.75 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPK1NPC1RAB9A | |
| SCHEMBL14158081 | 0.75 | AOC3 (0.48) | ALDH1A1NPC1RAB9APKMGAA | |
| SCHEMBL4250029 | 0.75 | NPC1 (0.63) | ALDH1A1MAPK1NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | NR1H4, NR1H3, NR1H2 | ALDH1A1 2656/4885LMNA 4487/4885MAPK1 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.