Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pimecrolimus. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A known ✓ | P62942 | 18/20 | 0.90 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | FKBP4 | Q02790 | 2/20 | 0.90 |
| ▸ | MEN1 | O00255 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.90 |
| ▸ | MAPT | P10636 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | THRB | P10828 | 1/20 | 0.90 |
| ▸ | PPP3CA | Q08209 | 2/20 | 0.79 |
| ▸ | MLNR | O43193 | 1/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.79 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.79 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.79 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.79 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.79 |
| ▸ | HTR2A | P28223 | 1/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimecrolimus SCHEMBL26411 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL3854625 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL8194907 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL4651515 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL438880 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL436549 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL9947518 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL4456276 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL15277958 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 | |
| Pimecrolimus SCHEMBL10241642 | 1.00 | ABCB11 (1.00) | ABCB11ADORA3FKBP1AFKBP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2413 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4504786-A1 | ENGINEERED CD200R ANTIBODIES AND USES THEREOF | MiroBio Limited (GB) | 2025-02-12 | — | — | EP | claimed |
| CN-119137150-A | Engineered CD200R antibodies and uses thereof | 米罗生物有限公司 | 2024-12-13 | — | — | CN | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| US-20230416361-A1 | ENGINEERED CD200R ANTIBODIES AND USES THEREOF | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2023-12-28 | — | — | US | claimed |
| WO-2023196866-A1 | ENGINEERED CD200R ANTIBODIES AND USES THEREOF | MIROBIO LIMITED (GB) | 2023-10-12 | — | — | WO | claimed |
| US-20210059981-A1 | COMPOUNDS AND FORMS OF TREATMENT FOR FEMALE SEXUAL DISORDERS | SHANAHAN MICHAEL E (US) | 2021-03-04 | — | — | US | claimed |
| CN-110536694-A | For treating pulmonary inflammatory composition and method | ATYR PHARMA INC | 2019-12-03 | — | — | CN | claimed |
| CN-110520097-A | Anhydrous compositions of MTOR inhibitors and methods of use thereof | PALVELLA THERAPEUTICS LLC | 2019-11-29 | — | — | CN | claimed |
| CN-105461693-B | CRTH2 agonist compounds and application thereof | 广东东阳光药业有限公司 | 2019-10-25 | — | — | CN | claimed |
| CN-110251182-A | A kind of umbellate form tissue plug | 凯斯蒂南京医疗器械有限公司 | 2019-09-20 | — | — | CN | claimed |
| CN-101918375-A | Benzodiazepinone compounds useful in the treatment of skin conditions | UNIV MICHIGAN | 2010-12-15 | — | — | CN | claimed |
| CN-101605529-A | Stabilization formulations and their preparation and using method | MACUSIGHT INC (US) | 2009-12-16 | — | — | CN | claimed |
| CN-101500937-A | Particles for delivery of active ingredients, process of making and compositions thereof | PANACEA BIOTEC LTD (IN) | 2009-08-05 | — | — | CN | claimed |
| CN-101355876-A | Methods, compositions and kits for treating medical conditions | COMBINATORX INC (US) | 2009-01-28 | — | — | CN | claimed |
| CN-101123878-A | L-threonine derivatives of high therapeutic index | SIGNATURE R & D HOLDINGS LLC (US) | 2008-02-13 | — | — | CN | claimed |
| WO-2007149868-A2 | CONTROLLED RELEASE ENCAPSULATED ANTI-BACTERIAL AND ANTI-INFLAMMATORY NANOPARTICLES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-12-27 | — | — | WO | claimed |
| CN-1925881-A | Biocompatible coatings for drug surfaces, methods and uses | HEMOTEQ GMBH (DE) | 2007-03-07 | — | — | CN | claimed |
| EP-1755672-A2 | METHODS AND ARTICLES FOR THE DELIVERY OF MEDICAMENTS TO THE EYE FOR THE TREATMENT OF POSTERIOR SEGMENT DISEASES | DIRECTCONTACT LLC (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110473-A2 | METHODS AND ARTICLES FOR THE DELIVERY OF MEDICAMENTS TO THE EYE FOR THE TREATMENT OF POSTERIOR SEGMENT DISEASES | DIRECTCONTACT LLC (US) | 2005-11-24 | — | — | WO | claimed |
| US-20050255144-A1 | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases | DIRECTCONTACT LLC | 2005-11-17 | — | — | US | claimed |